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In addition to radical rest as others suggested, have you tried medical interventions like Low Dose Abilify and Low Dose Naltrexone? For the latter, check out r/LowDoseNaltrexone — includes info on where to get it prescribed if your doctors won't. LDN may help with MCAS as well, although for that, have you tried DAO supplements before meals? (Like this: https://www.amazon.com/dp/B078K8L672 ) Recommended to me by an immunologist for MCAS, and it's made an enormous difference.